When Francine Russo suffers a nervous breakdown at "The Psychic Friends Network," she returns to her mother's house. She is broke, alone and about to turn forty. Anticipating nurturing, she finds instead that May, her mother, has taken in Andrew Cunningham, a "wanna be" stand up comedian. He is an outrageously funny, sick gay man her mother met on a pilgrimage to New Jersey where the Virgin Mary was appearing in a garage. May is busy tracking appearances of the Virgin around the world and planning Andrew's miraculous cure. On her fortieth birthday Francine confronts her mother about family secrets that have long rested in denial, keeping them estranged. The miraculous occurs in unexpected ways for all.