Miss Lucretia Collins once had young love and a bright future. Now she lives plagued with delusions in a small, decrepit apartment. Every night she imagines that Richard, her former love, breaks into her room to take advantage of her - but when she reports the intruder to the building manager, a doctor is called to come take her away.
A part of the collection 27 Wagons Full of Cotton and Other Plays.
Portrait of a Madonna premiered on Broadway at the Playhouse Theatre in April 1959 under the direction of Hume Cronyn.